Tips to Help Improve IVF Success Rate

IVF Success Rate

In vitro fertilization or IVF has by far proven to be the most effective method in the domain of assisted reproductive treatments for couples unable to conceive naturally. Ever since the birth of the first IVF baby Louise Joy Brown on 25th July, 1978 in England, followed by our very own Kanupriya Agarwal a little over two months later, the technique has been adopted by thousands of couples who are unable to conceive naturally. While it remains the most recommended treatment, it is important to understand certain dos and don’ts that contribute to the outcome.

How does the treatment work?

IVF involves retrieving mature eggs from ovaries and fertilizing those by sperm in a lab environment. The fertilized egg/s or embryo/s are then transferred into the uterus. One cycle of the entire complex series of procedures could take three weeks or longer. If multiple embryos are transferred to the uterus, there’s a chance of multiple pregnancy. The procedure can be performed using the couple’s own sperm and eggs or those from a donor. In certain cases, a gestational carrier is also used. Since IVF can be expensive and time-consuming, it’s extremely critical to understand and be aware of the dos and don’ts to boost your odds.

How can you increase the chances of your IVF success?

This is a generic checklist of tips you can use:

  • Choose your doctor and the embryology lab with care: Selecting the infertility specialist and a reliable fertility centre is critical for your success. Do a proper background research on the clinic’s credentials, success rates, lab environment, etc. It’ll be time well spent.
  • Eat healthy: Have a healthy, balanced diet that includes lots of fruits and vegetables, whole grains, legumes and fish, for your vitamin and protein needs, and go for foods rich in monounsaturated fats. Avoid processed foods and too much sugar.
  • Avoid alcohol and caffeine: Both alcohol and caffeine are known to impede the development of the foetus. So, it’s best to stay away from those.
  • Watch your weight: The success rate of IVF hinges a lot on your BMI or body mass index. So being overweight (with BMI in excess of 35) or underweight (BMI less than 19) can both harm your odds.
  • Control your stress: Stress has a direct adverse effect on the reproductive system and hence uncontrolled stress will surely hamper your chances. Pursue a de-stressing routine that works for you, like yoga or meditation or any other activity.
  • Sleep well: Aim for 8 hours of sleep a day and a normal sleep cycle for at least a couple of weeks leading up to your IVF appointment. It’s a good idea to retire early and avoid late nights.
  • Don’t overdo your exercise routine: A very strenuous exercise schedule can lower fertility levels and put you at risk of implantation failure and loss of pregnancy. So, stick to low-intensity workouts like walking, swimming or yoga.
  • Give up smoking: Smoking harms your health in many ways and severely dents your chances of achieving IVF success by affecting the quality of both egg and sperm. Quit now and seek support if you need to.
  • Take your supplements: Supplements your doctor prescribed can only do you good. A group of supplements like DHEA and CoQ10 have been linked to boosting both number and quality of eggs.
  • Watch your vitamin D count: Many of us have vitamin D deficiency without even knowing it. Emerging research has thrown up some linkages with D deficiency and impaired fertility as well as poor IVF outcomes. Take a D vitamin supplement if your levels are too low.
  • Avoid certain chemicals: Try to avoid certain chemicals during IVF like formaldehyde, parabens, triclosan, phenols, flame retardants, etc.
  • Stay patient and don’t give up: Patience and persistence are key to achieving IVF success. You have to accept the reality that it might take more than one IVF cycle to create an embryo for transfer. Sometimes, the doctor might tweak certain medications to try and achieve a better result in the next cycle. Here, it’s extremely important to stay patient and positive and help your fertility expert.

Certain medications can interfere with fertility drugs

Please inform your doctor if you are on any of these:

  • NSAIDs like aspirin or ibuprofen
  • Antidepressants
  • Steroids for asthma or lupus
  • Anti-epileptic medicines
  • Thyroid medications
  • Chemotherapy drugs

Remember when you sign up for IVF, you also agree to follow the doctor’s advice as she guides you through your journey. It is a partnership that will bear fruits only if you believe in your doctor, and above all in your abilities to comply with her guidelines.

Male Infertility: Causes & Impact

Male Infertility

Latest statistics reveal that 1 out of 7 couple is unable to conceive naturally. ‘Naturally’ would usually mean post a year of unprotected sexual intercourse. In our country the common tendency in such cases is to point the finger of doubt at the female partner. Yet, again, statistics reveal that in almost 50% of such cases the male partner is responsible. It is a problem that has shown an upward trend over the past years. Though it is difficult to zero in on the exact cause of this, changing lifestyle where stress and pressure of performance are two unignorable facts, is believed to be largely responsible.

Unfortunately, even in this day and age, our country has remained miles behind when it comes to either awareness or acceptance of the problem. The social stigma attached and presence of a strong male ego often prevents the men from going to the doctor and undergoing the relevant tests. This causes an inordinate delay in detection and subsequent treatment of the problem.

What causes male infertility?

Low sperm production and/or poor quality of sperm is the most common reason for male infertility. While even about three decades back sperm count in a normal Indian male was recorded at 60 million/ml, recent studies have revealed that it stands at 20 million/ml now. So, what has brought about this significant change? While factors like family history, chronic illness, and age are responsible, one cannot ignore the large role played by lifestyle factors like smoking, consumption of alcohol, and stress of modern day living. Sometimes, certain medical conditions or abnormalities (blockage) could be the cause.

Signs or symptoms to look out for

While there are no definite symptoms that would suggest infertility in males, inability to conceive is usually the first sign that indicates a fertility problem. Some other signs, however, could be indicative of male infertility. These include:

  • Difficulty with ejaculation
  • Poor volume of ejaculated fluid
  • Low sexual drive
  • Erectile dysfunction
  • Pain and swelling in the testicular area
  • Abnormal breast growth (a condition called gynecomastia)

If you are facing these issues, then it would be advisable to pay a visit to an infertility specialist without delay. Men with infertility issues are also known to be prone to recurrent respiratory infections, problems in the sense of smell and minimal growth of hair on the body.

What role does ‘male factor’ infertility play in conception?

The process of impregnation begins with the health of the sperm.

Are you producing healthy sperm? For this at least one of your testicles has to be functioning properly and your body has to produce the right quantity of hormones (including testosterone) to ensure a steady supply of sperm.

The journey begins: The sperm produced in the testicles are transported through thin tubes to the mix with semen before the final ejaculation.

Sperm count matters! The larger the number of sperm the more is the chance of fertilization of your partner’s egg. Fewer than 15 million sperm per millilitre of semen and less than 39 million per ejaculate is considered as low sperm count.

Sperm motility is important. Abnormal movement of sperm would mean that it is less likely to reach and impregnate the egg, hence motility of sperm plays a big role.

Sometimes certain Health conditions can lead to male infertility. These include:

Varicocele: Swelling of the veins that drain the testicle and reduce sperm quantity and quality

Infections can interfere with sperm production and health, and cause blockage in the pathway

Auto-immune disorders like diabetes: 1 in 4 men with type 2 diabetes are seen to have lower testosterone levels that is likely to lead to low sperm count, erectile dysfunction and low sexual drive.

Certain genetic disorders can lead to male infertility

Non-malignant tumours and treatment for testicular cancer can affect both the quantity and quality of sperm

Undescended testes is a condition where the testicles haven’t moved into their proper position. This increases risk of infertility and other medical conditions

Injury to the testes can be a cause of infertility as it may impact sperm production and motility

How is the condition diagnosed?

Post physical examination and understanding your family and medical history, the infertility specialist would typically advice some tests to check for the anomalies. These would include, semen and sperm analysis to check for the quantity, quality and motility of sperm. Sperm antibody and DNA tests are also recommended.

The role of Assisted Reproduction Techniques (ART)

Depending on the results of the prescribed test, the doctor may recommend hormone therapies and lifestyle modifications as an initial line of treatment, then follow up with choices of artificial reproduction techniques best suited to your condition. These could include:

Intracytoplasmic sperm injection (ICSI): Where a single sperm is injected into each egg to increase chances of fertilization

In Vitro Fertilization (IVF): Selected quality sperm from those donated by the male partner are used to increase chances of fertilization of egg in the laboratory