Miscarriage: Cause & Impact

miscarriage

A “spontaneous miscarriage” is the loss of a pregnancy before gestation of 20 weeks. Nearly 80% of spontaneous miscarriages occur within the first 12 weeks of pregnancy. While approximately one in four pregnancies end in miscarriage, many of these unfortunate events aren’t detected since these occur very early during pregnancy.

What causes a miscarriage?

A miscarriage usually occurs because the pregnancy is not developing properly. While a large number of miscarriages occur as a result of genetically abnormal embryos, there could be a plethora of factors responsible. These include:

# Random chromosome disorders

# Blood clotting disorders

# Hormonal disorders

# Submucosal fibroids

# Structural abnormalities in the womb

# Hormonal issues linked to polycystic ovaries

# An inherited genetic abnormality

# Being over 35 years of age, with a decline in quality of eggs

# For men over 40, the quality of sperm decreases, raising the risk of miscarriage

How does a woman understand that she’s having a miscarriage?    

Look out for the following signs:

# Heavy bleeding

# Severe abdominal or shoulder pain

# Fever or chills

# Dizziness or fainting

# Vaginal discharge with an unpleasant odor

# Diarrhoea or cramps

A miscarriage can trigger a whole gamut of emotional upheaval, particularly in the woman. Regardless of whether the pregnancy is planned or unplanned, the emotional impact of miscarriage can be great, and that’s perfectly normal. A sense of profound loss is very common and expected, and though people may react differently to this tragic event, the loss can bring on:

# A sense of total emptiness

# Anger and utter disbelief

# A crestfallen feeling

# Acute melancholy and a sense of isolation

But remember that it’s important to stay positive while riding out the emotional rollercoaster, and summon up enough courage and willpower to try again. This is when one needs the love and support of family and friends. Do not shut out the people who care for you and do not hesitate to turn to them for encouragement and support.

Do not give up hope, you have to try again!

However, while trying for another pregnancy after a miscarriage, remember to:

# Quit smoking

# Exercise regularly and follow a balanced diet

# Reduce stress

# Watch your weight

# Take folic acid tablets

Is any treatment required for a miscarriage?

Once a miscarriage has begun, it can’t be reversed. So the doctor would typically try to prevent heavy bleeding and infection as the main treatment protocols, besides providing emotional support. Heavy bleeding with clots and cramps would indicate that the patient is still passing the pregnancy tissue. These symptoms should settle once most of the pregnancy tissue has been passed.

Sometimes, following a miscarriage, some residual pregnancy tissue remains in the uterus. Doctors then use a spoon-shaped instrument called a curette to scrape the uterus, a procedure called ‘dilation and curettage’, usually performed under a light general anaesthetic and the patient can go home the same day.

The role of IVF in miscarriage

In recurrent miscarriages, IVF or In Vitro Fertilization with genetic testing “can significantly minimize the risk of miscarriage and improve chances for a safe and successful pregnancy”.

# Genetic screening: Since genetic abnormalities in the embryo are the most prevalent cause of miscarriage, genetic screening is a very useful tool.

# Embryo screening: Doctors can now screen for chromosomal abnormalities and identify the healthiest embryo for implantation with a very high degree of accuracy.

# Frozen embryo transfer: In thisform of IVF treatment, a cryopreserved embryo created in a full IVF cycle is thawed and transferred to a uterus.

# Single embryo transfer: In thisprocedure, a single embryo, selected from a larger pool of available embryos, is placed in the uterus. 

# Fertility care: This is extremely beneficial since tests prior to treatment can determine the risk for miscarriage and, possible contributing factors.

# Supervision & monitoring: Close supervision and monitoring is part of fertility care and helps mitigate risk and optimize chances for an ongoing pregnancy and live birth.

A miscarriage is more often than not precipitated by a combination of factors over which one had little control and it’s a wrong notion that the event has a propensity to recur. Women who have miscarried once or twice, are usually not sent for tests since it’s highly unlikely that anything would be found amiss. However, those who have had three back-to-back miscarriages, are at risk of miscarrying again, and must seek medical advice.

Diabetes: How does it affect fertility?

Diabetes and infertility

Scientific research has established that uncontrolled diabetes can affect fertility and reproductive health in both men and women. It is linked to hormonal disruptions, poor sperm quality and DNA damage, often resulting in irregular or absent menstrual cycles in women, while men could find it difficult to achieve and maintain erections.

What effect does diabetes have on fertility?

Diabetes can have different repercussions among women and men in terms of affecting fertility.

In women:

Infections: Women with diabetes are more prone to infections and damage to their reproductive organs, most commonly, the fallopian tubes.

Complications with pregnancy: Uncontrolled blood sugar levels can lead tomiscarriage or congenital defects in the foetus or even to ‘big baby syndrome’ or macrosomia.

Subdued libido: Most women with diabetes would suffer from fatigue, increased anxiety and depression, which could lead todecreased sexual desire. They can also feel pain and discomfort during sex because of decreased vaginal lubrication.

PCOS: Type 2 diabetes and obesity are also linked to PCOS or Polycystic Ovarian Syndrome, a metabolic disorder characterized by an excess of male hormones.

Anti-sperm antibodies: Diabetes can produce antibodies which may attack the sperms and even her eggs.

In men:

Sexual dysfunction: Men with diabetes often find it difficult to maintain an erection leading to infertility.

Decreased libido: Diabetic men also suffer from fatigue, weakness and loss of sexual drive, since certain areas of the brain don’t receive enough glucose, which is the only source of energy.

Damage to sperm DNA: Men with diabetes can experience impaired reproductive potency because of increased nuclear, mitochondrial and DNA damage.

Poor sperm quality: Type 2 diabetes is linked to poor sperm concentration in semen and also sub-par motility. Structural damage to the sperm and its DNA are also commonplace.

How is diabetes-related infertility treated?

A more holistic approach involving the couple’s respective family and medical histories is the ideal strategy. The aim is to achieve better control over the glycemic level and reproductive hormones and functions.

Some of the treatment options available are:

Medications: Treatment approach often startswith medications to stimulate ovulation in women, besides treating infections. Medications (sometimes coupled with hormonal supplements) are also used to treat issues like erectile dysfunction and premature ejaculation in men.

Surgical management: Surgical management often becomes a necessity to treat some cases of PCOS, uterine fibroids, trauma injuries, etc.

Advanced reproductive technologies (ART): For men, ART experts use procedures forsperm retrieval and intracytoplasmic sperm injection. For women, the methods generally deployed are in-vitro fertilization, intrauterine inseminationand assisted laser hatching.

However, it’s not all gloom and doom if you have diabetes and planning to start a family. It just requires early and comprehensive planning involving multiple specialties including endocrinologist, gynecologist and andrologist. The goal is to maintain your blood glucose levels at an optimum range to facilitate conception and maintain pregnancy till full-term. It’s all about cutting risks, watching your weight, eating right and meticulously following the advice of the doctors. Sometimes it will be absolutely necessary to seek help from a fertility expert as well.